World CRISPR Day 2021

Red, purple, green, and yellow A549 CRISPR cells.

World CRISPR Day 2021

Synthego Virtual Event

October 20, 2021

The Synthego World CRISPR Day Virtual Event provides a valuable platform for researchers to share and learn about the latest advancements in CRISPR. At this virtual event, we showcased our our collection of CRISPR/Cas9 gene-edited isogenic cell lines, EMT reporter cell lines, and luciferase-labeled cell lines.

Did you miss us at the event and want to speak to one of ATCC’s representatives about a product or service? Contact us so we can discuss your needs.

Cell line engineering

Gene-editing technologies like CRISPR work by making a double stranded break in the DNA of the gene you want to edit. The cell then tries to repair that damage and during that repair process the gene sequence at that location can be changed. The main challenges are directing the cutting enzymes (nucleases) to the right sequence (specificity), getting the nucleases to cut at that location a high percentage of the time (cutting efficiency), and directing the cell to repair the DNA using the desired new gene sequence (edit efficiency). Learn more about this fascinating technology and explore other technologies used for gene editing.

Learn more about gene-editing technologies

Featured CRISPR Resources

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Isogenic cells

Clinically relevant cell models are critical for studies of molecular and cellular mechanisms of tumors, as well as for drug screening for cancer. With genome editing tools such as CRISPR/Cas9, ATCC has created isogenic cell lines with mutants of key oncogenes, which are ideal for elucidating molecular pathways of cancer progression.

Explore isogenic cells

Fluorescent red and blue, red, and black colon cells.

EMT reporter cells

Epithelial-mesenchymal transition (EMT) and its reverse, MET, can play critical roles in promoting metastasis and invasion and contribute to drug resistance in carcinoma. ATCC used CRISPR gene editing to develop new reporter lines designed to enable the real-time monitoring of the changing status of cells from epithelial to mesenchymal.

Enhance your research

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Luciferase-labeled cell lines

ATCC is bridging the gap between the in vitro and the in vivo by offering luciferase-labeled cell lines for biological mechanism studies and drug development; these advanced models provide a relatively simple, robust, and highly sensitive means to measure biological processes and to assess drug efficacy in live animal models through bioluminescence imaging.

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