Streptomyces avermitilis (ex Burg et al.) Kim and Goodfellow (ATCC® 31267)

Strain Designations: NRRL 8165 [JCM 5070, MA-4680, NCIMB 12804]  /  Type Strain: yes  /  Biosafety Level: 1

Permits And Restrictions

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Deposited As Streptomyces avermitilis
Strain Designations NRRL 8165 [JCM 5070, MA-4680, NCIMB 12804]
Produces avermectin avermectins, avermectin B(1)a C-076, and C-076 and derivatives.
Soil, Ito City, Shizuoka Pref., Japan
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format freeze-dried
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Preceptrol® no
Genome Sequenced Strain

Streptomyces avermitilis MA-4680 DNA, complete genome.

Type Strain yes
Genome sequenced strain
Medium ATCC® Medium 184: Glucose asparagine agar
Growth Conditions
Temperature: 26°C
Atmosphere: Aerobic
Name of Depositor NRRL
U.S. Patent Number
Disclosure This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished.
Special Collection NSF - Bacteriology
Chain of Custody
ATCC <-- NRRL <-- Merck & Co., Inc. MA-4680
Soil, Ito City, Shizuoka Pref., Japan

Burg RW, et al. Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation. Antimicrob. Agents Chemother. 15: 361-367, 1979. PubMed: 464561

Goegelman RT, et al. Novel C-076 compounds. US Patent 4,378,353 dated Mar 26 1983

Hafner EW, et al. Cultures for production of B avermectins. US Patent 5,565,359 dated Oct 15 1996

Ikeda H, et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat. Biotechnol. 21: 526-531, 2003. PubMed: 12692562

Kim SB, Goodfellow M. Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. Int. J. Syst. Evol. Microbiol. 52: 2011-2014, 2002. PubMed: 12508861

Miller TW, et al. Avermectins, new family of potent anthelmintic agents: Isolation and chromatographic properties. Antimicrob. Agents Chemother. 15: 368-371, 1979. PubMed: 464562

Ormond RE. 22-Hydroxy derivatives of C-076 compounds, pharmaceutical compositions and method of use. US Patent 4,412,991 dated Nov 1 1983

Cross References

Nucleotide (GenBank) : AY029771 Streptomyces avermitilis ribosomal protein S12 (rpsL) gene, complete cds.

Nucleotide (GenBank) : BA000030 Streptomyces avermitilis MA-4680 DNA, complete genome.

Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation