Planned maintenance

We must perform activities that will impact the ability to place orders on our website. Starting Friday, May 21, at 5:00 p.m. Eastern to Sunday, May 23, at 5:00 p.m. Eastern, you will not be able to order products on our website. You will still be able to browse and access your account. We apologize for any inconvenience this work may cause.

CRISPR-edited Isogenic Cell Models Video

CRISPR/Cas9 genome editing technology is one of the most outstanding scientific breakthroughs in recent years, revolutionizing basic and medical research by enabling site-specific genome engineering of cell lines.

ATCC has mastered the science and art of CRISPR gene-editing. We take highly authenticated cell lines from our collection and introduce disease-relevant mutations using the CRISPR/Cas9 system to modify regions of interest in the genome, and then rigorously screen the gene-edited isogenic cell clones.

ATCC CRISPR gene-edited cell lines are:

  • Precisely gene edited
  • Engineered on commonly used tumor cell lines
  • Highly relevant to diseases and drug targets
  • Validated at genomic, transcript, and protein levels
  • Biofunctional characterization with specific inhibitors
  • Well suited for drug screening applications