This cell line is a derivative of HCT 116 in which one copy of the ATR gene has been disrupted, and the other allele has been fixed with lox sites flanking exon 2 making it susceptible to Cre deletion.
Cortez D, et al. ATR and ATRIP: partners in checkpoint signaling. Science 294: 1713-1716, 2001. PubMed: 11721054