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The Cyt c -/- cell line was derived from a cytochrome c null mouse embryo at E8/E9 (8-9 days gestation) prior to embryonic death.
Cytochrome c released from mitochondria has been proposed to be an essential component of an apoptotic pathway responsive to DNA damage and other forms of cell stress.
The Cyt c -/- cells are devoid of cytochrome c and are resistant to various types of apoptotic stimuli.
They show reduced caspase-3 activation and are resistant to the proapoptotic effects of UV irradiation, serum withdrawal, and staurosporine.
They demonstrate increased sensitivity to cell death signals triggered by TNFalpha.
The Cyt c-/- cell line provides a unique resource of mammalian cells lacking cytochrome c.