Streptomyces rapamycinicus Kumar and Goodfellow (ATCC® 29253)

Strain Designations: AY B-994 [NRRL 5491]  /  Type Strain: yes  /  Biosafety Level: 1

Deposited As Streptomyces hygroscopicus subsp. hygroscopicus (Jensen) Waksman and Henrici
Strain Designations AY B-994 [NRRL 5491]
Application
Produces sirolimus rapamycin
Isolation
Soil, Easter Island
Type Strain yes
Biosafety Level 1
Product Format freeze-dried
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Preceptrol® no
Type Strain yes
Medium Medium 1877: ISP Medium 1
Medium 334: Oatmeal agar
Growth Conditions
Temperature: 26°C
Atmosphere: Aerobic
Name of Depositor C Vezina
Isolation
Soil, Easter Island
References

Kumar Y, Goodfellow M. Five new members of the Streptomyces violaceusniger 16S rRNA gene clade: Streptomyces castelarensis sp. nov., comb. nov., Streptomyces himastatinicus sp. nov., Streptomyces mordarskii sp. nov., Streptomyces rapamycinicus sp. nov. and Streptomyces ruanii sp. nov. Int. J. Syst. Evol. Microbiol. 58: 1369-1378, 2008. PubMed 18523180

Vezina C, et al. Rapamycin (AY-22,989), a new antifungal antibiotic. I. Taxonomy of the producing streptomycete and isolation of the active principle. J. Antibiot. 28: 721-726, 1975. PubMed: 1102508

Cross References

Nucleotide (GenBank) : AF007101 Streptomyces hygroscopicus putative pteridine-dependent dioxygenase, PKS modules 1,2,3 and 4, and putative regulatory protein genes, complete cds and putative hydroxylase gene, partial cds.

Nucleotide (GenBank) : EF408733 Streptomyces hygroscopicus strain NRRL B-5491 16S ribosomal RNA gene, partial sequence