Mutations in IDH1 are found in approximately 80% of grade II-III gliomas and secondary glioblastomas in humans. A single amino acid residue of IDH1, arginine 132, is most commonly mutated to histidine. This IDH1 R132H mutation results in a gain-of-function to produce oncometabolilte 2-hydroxyglutarate.
|Date Created||03/29/2013 12:04 PM
|Date Updated||03/27/2014 08:41 PM