Although both series of cell line panels have genetic alteration information, the panel designs and data validation levels are different. The tumor cell panels by tissue type are based on the cancer disease type and the tissue of tumor origin, and are more suitable for researchers focused on specific cancer disease. Cell lines within these panels are annotated with gene mutation data that developed by Sanger Institute COSMIC database. The tumor cell panels by molecular signature are more suitable for researchers focused on molecular mechanism or targeted drug development. The molecular signature panels are based on cancer genes or key component of cell signaling pathways. Cell lines within molecular signature panels have been fully validated by ATCC to verify mutations, gene copy number changes, gene expression, protein expression and cell functionalities.
|Date Created||10/15/2013 11:30 AM
|Date Updated||03/27/2014 08:42 PM