The EML4-ALK gene fusion that is caused by a chromosomal inversion can produce constitutively active ALK tyrosine kinase protein, which leads to enhanced cell survival and proliferation. There are multiple EML4-ALK fusion variants, and the most prevalent is variant 1 (E13; A20) where the EML4 intron 13 is fused with ALK intron 20. The EML4-ALK Fusion-A549 Isogenic cells (ATCC®
CCL-185IG ™) was created at ATCC using CRISPR/Cas9 gene editing technology and contains the EML4-ALK fusion variant 1 (E13; A20).
|Date Created||01/18/2016 10:19 AM
|Date Updated||01/18/2016 10:20 AM