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Cells contain herpesvirus
ATCC highly recommends that appropriate personal protective equipment is always used when handling vials. For cultures that require storage in liquid nitrogen, it is important to note that some vials may leak when submersed in liquid nitrogen and will slowly fill with liquid nitrogen. Upon thawing, the conversion of the liquid nitrogen back to its gas phase may result in the vial exploding or blowing off its cap with dangerous force creating flying debris. Unless necessary, ATCC recommends that these cultures be stored in the vapor phase of liquid nitrogen rather than submersed in liquid nitrogen.
Expression of EBNA-1 permits episomal replication of expression vectors such as pDC406 that contain the EBV origin of replication. The cells can be used as host for expression of transfected DNA.
The line was derived from CV-1 (ATCC CCL-70) by transfection with a plasmid encoding Epstein Barr Virus nuclear antigen 1 (EBNA-1).
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McMahan CJ, et al. A novel IL-1 receptor, cloned from B cells by mammalian expression, is expressed in many cell types. EMBO J. 10: 2821-2832, 1991. PubMed: 1833184
Gearing DP. Receptor for oncostatin M and leukemia inhibitory factor. US Patent 5,262,522 dated Nov 16 1993