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Influenza A virus (H1N1) (ATCC® VR-1672™)

Classification: Orthomyxoviridae, Influenzavirus A  /  Product Format: frozen

Classification Orthomyxoviridae, Influenzavirus A
Agent Influenza A virus (H1N1)
Strain Monoclonal Anti-Influenza Virus H1 Hemagglutinin (HA), A/South Carolina/1/1918 (H1N1), clone 58C4 (produced in vitro)
Applications
Emerging infectious disease research
Respiratory research
Influenza Research
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Product Format frozen
Storage Conditions  -20°C or colder Repeated freeze-thaw cycles should be avoided
Comments
Antibody Class: IgG2bκ
The B cell hybridoma was generated by the fusion of Sp2/0 BALB/c mouse myeloma cells with splenocytes from mice immunized by DNA vaccination with a plasmid encoding the HA of influenza virus, A/South Carolina/1/1918 (H1N1) and then boosted with whole inactivated virus.
Name of Depositor A Garcia-Sastre, Mount Sinai School of Medicine, New York, New York
Source
Mouse monoclonal antibody prepared against the H1 hemagglutinin (HA) of influenza virus, A/South Carolina/1/1918 (H1N1) was purified from clone 58C4 hybridoma supernatant by protein G affinity chromatography.
References

Glaser L, et al. A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. J. Virol. 79: 11533-11536, 2005. PubMed: 16103207

Manicassamy B, et al. Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines. PLoS Pathog. 6: e1000745, 2010. PubMed: 20126449

Tumpey TM, et al. Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus. Proc. Natl. Acad. Sci. USA. 99: 13849-13854, 2002. PubMed: 12368467