Herpesvirus saimiri (ATCC® VR-1396)

Classification: Herpesviridae, Rhadinovirus  /  Product Format: frozen

Permits and Restrictions

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Classification Herpesviridae, Rhadinovirus
Agent Herpesvirus saimiri
Strain C-488
Common Name Herpesvirus saimiri
Biosafety Level 2

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format frozen
Storage Conditions -70°C or colder
Comments This item contains FBS of Guatemalan origin. Strain is also available as ATCC® VR-1414™, which does not require a USDA permit due to multiple passages of ATCC® VR-1396™ in US origin FBS.

Herpesvirus saimiri strain C488 transforms human T lymphocytes to antigen- and mitogen-independent, but IL-2 dependent stable growth. Virus stocks are stable for months at 4C, but titer greatly reduced by freeze-thaw cycles.

For methods of propagation see: Fickenscher and Fleckenstein, 1994. in: Methods in Molecular Genetics. (ed) K. W. Adolph, 4: 345-362, 1994.
Effect on Host
CPE, foci of detached cells bordered by rounded enlarged cells
Recommended Host
OMK (ATCC® CRL-1556™)
Growth Conditions
Temperature: 37°C

Incubation:  Incubate infected culture for 10-20 days at 37°C in a humidified 5% CO2 atmosphere, until CPE are well advance

Effect on Host
CPE, foci of detached cells bordered by rounded enlarged cells
Name of Depositor M Daniel, R Desrosiers, B Biesinger, B Fleckenstein, H Fickenscher
Special Collection NCRR Contract
Source Blood lymphocytes of New England Regional Primate Research Ctr. squirrel monkey (Saimiri sciureus)

Biesinger B, et al. The divergence between two oncogenic Herpesvirus saimiri strains in a genomic region related to the transforming phenotype. Virology 176: 505-514, 1990. PubMed: 2161148

Desrosiers RC, Falk LA. Herpesvirus saimiri strain variability. J. Virol. 43: 352-356, 1982. PubMed: 6287011

Biesinger B, et al. Stable growth transformation of human T lymphocytes by herpesvirus saimiri. Proc. Natl. Acad. Sci. USA 89: 3116-3119, 1992. PubMed: 1313581

. Methods in Molecular Genetics, Part A. : K.W. Adolph; 1993.

Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • USDA APHIS VS 16-6 or 16-6A permit must be obtained and a copy of the permit must be sent to ATCC in advance of shipment. The Application Form VS 16-3 (Import controlled material import or transport organisms or vectors) must be submitted to USDA APHIS Veterinary Services to obtain the VS 16-6 or 16-6A permit.
  • Customer Acceptance of Responsibility, ATCC Form 62 required for distribution.
  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation