B2EE-2.0 (ATCC® 61490)

Organism: Homo sapiens, human  /  Clone Type: Clone  /  Depositors: R Baer

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Designations B2EE-2.0
Species Homo sapiens, human
Depositors R Baer
Construct size (kb): 4.699999809265137
DNA: genomic
Insert lengths(kb): 2.0
Tissue: T-acute lymphocytic leukemia T-lymphocyte
Gene product: T-cell acute lymphocytic leukemia 1 (NOTE: redefinition of symbol)(T cell lymphoma 5, helix-loop-helix protein tal-1, 34 kDa) [TAL*]
Insert Size (kb) 2.0
Media ATCC® Medium 1227: LB Medium (ATCC medium 1065) with 50 mcg/ml ampicillin
Biosafety Level 1
Shipping Information Distributed: freeze-dried
Restriction digests of the clone give the following sizes (kb): EcoRI--2.8, 2.0; HindIII--4.7; BamHI--4.7; PstI--4.7; SalI--4.7.
The translocation breakpoint on chromosome 14 in the 2 patients characterized occurred either immediately upstream of Ddelta2-Jdelta1 sequences or within Jdelta1 sequences of the T cell receptor.
The insert is derived from sequences adjacent to or involved in translocations in 2 T-ALL patients t(1;14)(p32;q11) and retained on the der(1) chromosome.

Chen Q, et al. The tal gene undergoes chromosme translocation in T cell leukemia and potentially encodes a helix-loop-helix protein. EMBO J. 9: 415-424, 1990. PubMed: 2303035

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