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Histoplasma capsulatum Darling (ATCC® 26032™)

Alternate State: Ajellomyces capsulatus (Kwon-Chung) McGinnis et Katz, teleomorph  /  Strain Designations: G-217B  /  Product Format: frozen

Deposited As Histoplasma capsulatum Darling, anamorph
Strain Designations G-217B
Alternate State Ajellomyces capsulatus (Kwon-Chung) McGinnis et Katz, teleomorph
Application
Biomedical Research and Development Material
Emerging infectious disease research
Respiratory research
Biosafety Level 3

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.
Product Format frozen
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Type Strain no
Preceptrol® no
Genome Sequenced Strain

Yes

Comments
iron acquisition mechanisms
fungistasis
neutralization of interleukin-12
yeast phase
effect of continuous light and total darkness
effect of pH
differentiation of A and B phenotypes
temperature-tolerant, high virulence; analysis of yps-3 gene
Genome sequencing strain (The Genome Sequencing Center (GSC) at Washington University, USA).
Medium ATCC® Medium 28: Emmons' modification of Sabouraud's agar
Growth Conditions
Temperature: 25.0°C
Name of Depositor MD Berliner
Chain of Custody
ATCC <<--MD Berliner<<--J.H. Seabury
Isolation
human, Louisiana
Cross References

Nucleotide (GenBank) : AF026268 M antigen gene, complete coding sequence

Nucleotide (GenBank) : AF139985 catalase B (CATB) mRNA, complete coding sequence

Nucleotide (GenBank) : AF189368 catalase isozyme A (CATA) mRNA, complete coding sequence

Nucleotide (GenBank) : AF189369 catalase isozyme P (CATP) mRNA, complete coding sequence

Nucleotide (GenBank) : L16844 Histoplasma capsulatum yeast phase specific (yps-3) gene, complete

Nucleotide (GenBank) : L16845 Histoplasma capsulatum yeast phase specific (yps-3) mRNA, 3' end of

Complete Genome (GenBank) : ABBT00000000 Ajellomyces capsulatus G217B, whole genome shotgun sequencing project

References

Keath EJ, Abidi FE. Molecular cloning and sequence analysis of yps-3, a yeast-phase-specific gene in the dimorphic fungal pathogen Histoplasma capsulatum. Microbiology 140: 759-767, 1994. PubMed: 8012597

Berliner MD, Biundo N Jr.. Effects of continuous light and total darkness on cultures of Histoplasma capsulatum. Sabouraudia 11: 48-51, 1973. PubMed: 4703465

Berliner MD. Histoplasma capsulatum: effects of pH on the yeast and mycelial phases in vitro. Sabouraudia 11: 267-270, 1973. PubMed: 4128915

Berliner MD. Histoplasma capsulatum: vital staining for the differentiation of the albino and brown phenotypes in vitro. Sabouraudia 11: 271-273, 1973. PubMed: 4128916

Weaver CH, et al. Localization of a yeast-phase-specific gene product to the cell wall in Histoplasma capsulatum. Infect. Immun. 64: 3048-3054, 1996. PubMed: 8757832

Timmerman MM, Woods JP. Ferric reduction is a potential iron acquisition mechanism for histoplasma capsulatum. Infect. Immun. 67: 6403-6408, 1999. PubMed: 10569756

Cain JA, Deepe GS Jr.. Interleukin-12 neutralization alters lung inflammation and leukocyte expression of CD80, CD86, and major histocompatibility complex class II in mice infected with Histoplasma capsulatum. Infect. Immun. 68: 2069-2076, 2000. PubMed: 10722603

Sorensen KN, et al. Murine models of blastomycosis, coccidioidomycosis, and histoplasmosis. Mycopathologia 146: 53-65, 1999.

Newman SL, et al. Identification of constituents of human neutrophil azurophil granules that mediate fungistasis against Histoplasma capsulatum. Infect. Immun. 68: 5668-5672, 2000. PubMed: 10992469

Johnson CH, et al. Redundancey, phylogeny and differential expression of Histoplasma capsulatum catalases. Microbiology 148: 1129-1142, 2002. PubMed: 11932457

Magrini V, et al. Fosmid-Based Physical Mapping of the Histoplasma capsulatum Genome. Genome Res. 14: 1603-1609, 2004.