Histoplasma capsulatum Darling (ATCC® 12700)

Alternate State: Ajellomyces capsulatus (Kwon-Chung) McGinnis et Katz, teleomorph  /  Strain Designations: 6624 [ATCC 28307, CDC A811]  /  Product Format: frozen

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Deposited As Histoplasma capsulatum Darling, anamorph
Strain Designations 6624 [ATCC 28307, CDC A811]
Alternate State Ajellomyces capsulatus (Kwon-Chung) McGinnis et Katz, teleomorph
Biomedical Research and Development Material
Emerging infectious disease research
Respiratory research
Biosafety Level 3

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format frozen
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Type Strain no
Preceptrol® no
human lymphocyte blastogenesis
mycelial and yeast forms
CF Reactivity
uric acid in ecology of Histoplasma capsulatum
uptake of sulfur-containing compounds
method for isolation
GC content
maintenance of mycelial phase
differentiation of Histoplasma capsulatum and H. duboisii
fluorescent antibody studies
differentiation from other pathogens
Chitinase re antigenicity
enzymatic hydrolysis
inhibition by rabbit alveolar macrophage lysosomal extract
Medium ATCC® Medium 906: Pine and Drouhet's Histoplasma yeast-phase medium
Growth Conditions
Temperature: 37.0°C
Name of Depositor L Pine
Chain of Custody
ATCC <<--L Pine<<--C.W. Emmons
sputum, Ohio

Ehrhard HB, Pine L. Factors influencing the production of H and M antigens by Histoplasma capsulatum: development and evaluation of a shake culture procedure. Appl. Microbiol. 23: 236-249, 1972. PubMed: 4622821

Ehrhard HB, Pine L. Factors influencing the production of H and M antigens by Histoplasma capsulatum: effect of physical factors and composition of medium. Appl. Microbiol. 23: 250-261, 1972. PubMed: 4622822

Bawdon RE, et al. Deoxyribonucleic acid base composition of the yeastlike and mycelial phases of Histoplasma capsulatum and Blastomyces dermatitidis. J. Bacteriol. 111: 593-596, 1972. PubMed: 5053471

Pine L, et al. Studies on the thermal degradation of the H and M antigens of lyophilized histoplasmin. Sabouraudia 19: 55-70, 1981. PubMed: 6164105

Alford RH, Cartwright BB. Human lymphocyte blastogenesis induced by living and dead Histoplasma capsulatum yeasts and soluble yeast autolysate. Sabouraudia 19: 85-95, 1981. PubMed: 7256491

Calderone RA, Peterson E. Inhibition of amino acid uptake and incorporation into Histoplasma capsulatum by a lysosomal extract from rabbit alveolar macrophages. J. Reticuloendothel. Soc. 26: 11-19, 1979. PubMed: 490508

Reiss E. Serial enzymatic hydrolysis of cell walls of two serotypes of yeast- form Histoplasma capsulatum with alpha(1 leads to 3)-glucanase, beta(1 leads to 3)-glucanase, pronase, and chitinase. Infect. Immun. 16: 181-188, 1977. PubMed: 873605

Kaufman L, Kaplan W. Preparation of a fluorescent antibody specific for the yeast phase of Histoplasma capsulatum. J. Bacteriol. 82: 729-735, 1961. PubMed: 14454457

Kaufman L, Brandt B. Fluorescent-antibody studies of the mycelial form of Histoplasma capsulatum and morphologically similar fungi . J. Bacteriol. 87: 120-126, 1964. PubMed: 14102844

Garrison RG, Gordon L. A concentration and cultural method for the enhanced isolation of Histoplasma capsulatum from sputum. Health Lab. Sci. 8: 231-237, 1971. PubMed: 5115118

. . Contrib. Microbiol. Immunol. 3: 138-168, 1977.

Pine L. Growth of Histoplasma capsulatum. VI. Maintenance of the mycelial phase. Appl. Microbiol. 19: 413-420, 1970. PubMed: 5440171

Pine L. Growth on amino acids, cell wall proteins, and hydrolysis of yeast phase cell walls of Histoplasma capsulatum and H. duboisii. Sabouraudia 10: 244-255, 1972. PubMed: 4640042

Odds FC, et al. Effect of chitinase complex on the antigenicity and chemistry of yeast- form cell walls and other fractions of Histoplasma capsulatum and Blastomyces dermatitidis. Sabouraudia 12: 138-149, 1974. PubMed: 4604380

Li M, et al. Complement fixing cross reactivity between Histoplasma capsulatum and certain form-related aleuriosporic Hyphomycetes. Mycopathol. Mycol. Appl. 33: 353-363, 1967. PubMed: 4967884

Lockwood GF, Garrison RG. The possibel role of uric acid in the ecology of Histoplasma capsulatum. Mycopathol. Mycol. Appl. 35: 377-388, 1968. PubMed: 5696730

Garrison RG, et al. The uptake of low molecular weight sulfur-containing compounds by Histoplasma capsulatum and related dimorphic fungi. Mycopathol. Mycol. Appl. 40: 171-180, 1970. PubMed: 5455792

Kaufman L, Blumer S. Occurrence of serotypes among Histoplasma capsulatum strains. J. Bacteriol. 91: 1434-1439, 1966. PubMed: 5326107

Kaufman L, Blumer S. Development and use of a polyvalent conjugate to differentiate Histoplasma capsulatum and Histoplasma duboisii from other pathogens. J. Bacteriol. 95: 1243-1246, 1968. PubMed: 4869210

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