Derivation
|
The RHCT-138 cell line was derived from a skin biopsy taken from an HTLV-1 infected rabbit (X138) with cutaneous T cell lymphoma (CTCL). The rabbit developed chronic HTLV-1 infection after inoculation with the infected rabbit T cell line RH/K34 (see ATCC CRL-2560). Approximately 20 months after inoculation, the rabbit developed a generalized exfoliative papillated dermatopathy. Cutaneous lesions were biopsied.
|
Genes Expressed
|
HTLV-I (human T cell leukemia virus)
|
Cellular Products
|
HTLV-I (human T cell leukemia virus)
|
Comments
|
The RHCT-138 cell line was derived from a skin biopsy taken from an HTLV-1 infected rabbit (X138) with cutaneous T cell lymphoma (CTCL). The rabbit developed chronic HTLV-1 infection after inoculation with the infected rabbit T cell line RH/K34 (see ATCC CRL-2560). Approximately 20 months after inoculation, the rabbit developed a generalized exfoliative papillated dermatopathy. Cutaneous lesions were biopsied. The cell line harbors productively infected, monoclonally integrated, full length HTLV-1. The HTLV-1 sequences in the skin likely represent the presence of infected T cells in epidermotropic lymphoid infiltrates.
|