Acremonium chrysogenum (Thirumalachar et Sukapure) Gams, anamorph (ATCC® 14553)

Strain Designations: 8650  /  Product Format: freeze-dried

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Deposited As Cephalosporium sp.
Strain Designations 8650
produces cephalosporin C
produces cephalosporins
produces deacetoxycephalosporin C
produces penicillin
transformation host
produces: arthospore-inducing substances for production of cephalosporin C
Biosafety Level 1
Product Format freeze-dried
Type Strain no
Preceptrol® no
transformation using a vector without bacterial DNA
Carries plasmid pAC1 for preparing a hybrid vector which promotes the biosynthesis of beta-lactam antibiotics
polymorphic karyotype
Medium ATCC® Medium 335: Potato carrot agar
Growth Conditions
Temperature: 24.0°C
Name of Depositor RC Godner
Mutant of ATCC 11550
Cross References

Nucleotide (GenBank) : X72789 beta-tubulin gene


Kelly BK, et al. Production of cephalosporin C. US Patent 3,082,155 dated Mar 19 1963

Nakao Y, et al. Production of deacetoxycephalosporin C. US Patent 3,979,260 dated Sep 7 1976

Katamoto K, et al. Method for separating cephalosporins. US Patent 4,535,155 dated Aug 13 1985

Esser K, Minuth W. Plasmid pAC 1, a process for obtaining it and its use. US Patent 4,506,014 dated Mar 19 1985

Walz M, Kuck U. Polymorphic karyotypes in related Acremonium strains. Curr. Genet. 19: 73-76, 1991. PubMed: 1676616

Nowak C, Kuck U. Development of an homologous transformation system for Acremonium chrysogenum based on the beta-tubulin gene. Curr. Genet. 25: 34-40, 1994. PubMed: 8082163

Menne S, et al. Expression studies with the bidirectional pcbAB-pcbC promoter region from Acremonium chrysogenum using reporter gene fusions. Appl. Microbiol. Biotechnol. 42: 57-66, 1994. PubMed: 7765820

Nowak C, et al. DNA-mediated transformation of a fungus employing a vector devoid of bacterial DNA sequences. Appl. Microbiol. Biotechnol. 43: 1077-1081, 1995. PubMed: 8590659

Shirafuji H, et al. Accumulation of tripeptide derivatives by mutants of Cephalosporium acremonium. Agric. Biol. Chem. 43: 155-160, 1979.

Natsume M, Marumo S. Arthrospore-inducing substances from Acremonium chrysogenum which stimulate cephalosporin C production. Agric. Biol. Chem. 48: 567-569, 1984.

Huber FM, Redstone MO. Changes in the fatty acids of Cephalosporium acremonium Corda and its growth medium. Can. J. Microbiol. 13: 332-334, 1969.

Lemke PA, Nash CH. Mutations that affect antibiotic synthesis by Cephalosporium acremonium. Can. J. Microbiol. 18: 255-259, 1972. PubMed: 4336241

Queener SW, et al. Glutamate dehydrogenase specific activity and cephalosporin C synthesis in the M8650 series of Cephalosporium acremonium mutants. Antimicrob. Agents Chemother. 7: 646-651, 1975. PubMed: 1170808

Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation