Candida dubliniensis Sullivan et al. (ATCC® MYA-646)

Strain Designations: CBS 7987 [ATCC MYA-178, CD 36, NCPF 3949, NRRL Y-17841]  /  Product Format: frozen

Deposited As Candida dubliniensis Sullivan et al., anamorph
Strain Designations CBS 7987 [ATCC MYA-178, CD 36, NCPF 3949, NRRL Y-17841]
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format frozen
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Type Strain yes
Preceptrol® no
Genome Sequenced Strain


Genome sequencing strain (Sanger Institute, UK).
Mitochondrial genome sequenced strain
Morphology After 3 days at 25°C colonies white to cream-colored, glistening, soft and smooth.  Cells are globose to ovoidal.
Medium ATCC® Medium 28: Emmons' modification of Sabouraud's agar
ATCC® Medium 200: YM agar or YM broth
ATCC® Medium 1245: YEPD
Growth Conditions
Temperature: 24°C to 26°C
Atmosphere: Typical aerobic
Sequenced Data
18S ribosomal RNA gene, partial sequence; internal   transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 26S ribosomal RNA gene, partial sequence


D1D2 region of the 26S ribosomal RNA gene


Morphology After 3 days at 25°C colonies white to cream-colored, glistening, soft and smooth.  Cells are globose to ovoidal.
Name of Depositor SA Meyer
Special Collection NCRR Contract
Chain of Custody
ATCC <-- SA Meyer <-- CBS 7987 <-- D.C. Coleman CD 36
Oral cavity of HIV-infected patient, Dublin, Ireland
Cross References

Nucleotide (GenBank) : JQ070170 D1/D2 region of 28S rRNA gene

Nucleotide (GenBank) : JQ070103 ITS including 5.8S rRNA gene


Sullivan DJ, et al. Candida dubliniensis sp. nov.: phenotypic and molecular characterization of a novel species associated with oral candidosis in HIV-infected individuals. Microbiology 141: 1507-1521, 1995. PubMed: 7551019

Kurtzman CP, Robnett CJ. Identification of clinically important ascomycetous yeasts based on nucleotide divergence in the 5' end of the large-subunit (26S) ribosomal DNA gene. J Clin Microbiol 35: 1216-1223, 1997. PubMed: 9114410

Valach M, et al. Evolution of linear chromosomes and multipartite genomes in yeast mitochondria. Nucleic Acids Res. 39: 4202-4219, 2011.

Cornet M, et al. Molecular identification of closely related Candida species using two ribosomal intergenic spacer fingerprinting methods. J Mol Diagn 13: 12-22, 2011. PubMed: 21227390

Arendrup MC, et al. Echinocandin susceptibility testing of Candida species: comparison of EUCAST EDef 7.1, CLSI M27-A3, Etest, disk diffusion, and agar dilution methods with RPMI and isosensitest media. Antimicrob. Agents Chemother 54: 426-439, 2010. PubMed: 19884370

Loaiza-Loeza S, et al. Differential expression of Candida dubliniensis-secreted aspartyl proteinase genes (CdSAP1-4) under different physiological conditions and during infection of a keratinocyte culture. FEMS Immunol Med Microbiol 56: 212-222, 2009. PubMed: 19538512

Jackson AP, et al. Comparative genomics of the fungal pathogens Candida dubliniensis and Candida albicans. Genome Res. 19: 2231-2244, 2009. PubMed: 19745113

Innings A, et al. Multiplex real-time PCR targeting the RNase P RNA gene for detection and identification of Candida species in blood. J Clin Microbiol 45: 874-880, 2007. PubMed: 17215340

Moran G, et al. Comparative genomics using Candida albicans DNA microarrays reveals absence and divergence of virulence-associated genes in Candida dubliniensis. Microbiology 150: 3363-3382, 2004. PubMed: 15470115

Diezmann S, et al. Phylogeny and evolution of medical species of Candida and related taxa: a multigenic analysis. J Clin Microbiol 42: 5624-5635, 2004. PubMed: 15583292

Pinjon E, et al. Molecular mechanisms of itraconazole resistance in Candida dubliniensis. Antimicrob. Agents Chemothe.r 47: 2424-2437, 2003. PubMed: 12878500

Perea S, et al. Molecular mechanisms of fluconazole resistance in Candida dubliniensis isolates from human immunodeficiency virus-infected patients with oropharyngeal candidiasis. Antimicrob Agents Chemother 46: 1695-1703, 2002. PubMed: 12019078

Tamura M, et al. Molecular characterization of new clinical isolates of Candida albicans and C. dubliniensis in Japan: analysis reveals a new genotype of C. albicans with group I intron. J. Clin. Microbiol. 39: 4309-4315, 2001. PubMed: 11724837

Yokoyama K, et al. Identification and phylogenetic relationship of the most common pathogenic Candida species inferred from mitochondrial cytochrome b gene sequences. J Clin Microbiol 38: 4503-4510, 2000. PubMed: 11101587

Heinz WJ, et al. Molecular responses to changes in the environmental pH are conserved between the fungal pathogens Candida dubliniensis and Candida albicans. Int J Med Microbiol 290: 231-238, 2000. PubMed: 10959725

Daniel HM, Sorrell TC, Meyer W. Partial sequence analysis of the actin gene and its potential for studying the phylogeny of Candida species and their teleomorphs. Int J Syst Evol Microbiol 51: 1593-1606, 2001. PubMed: 11491363

Staib P, et al. Isogenic strain construction and gene targeting in Candida dubliniensis. J. Bacteriol. 183: 2859-2865, 2001. PubMed: 11292806

Tintelnot K, et al. Evaluation of phenotypic markers for selection and identification of Candida dubliniensis. J. Clin. Microbiol. 38: 1599-1608, 2000. PubMed: 10747150

Tamura M, et al. New PCR primer pairs specific for Candida dubliniensis and detection of the fungi from the Candida albicans clinical isolates in Japan. Clin. Lab. 46: 33-40, 2000. PubMed: 10745979