The C-33 A cell line is one of a series of lines (see also ATCC CRL-1594
and ATCC CRL-1595)
derived by N. Auersperg from cervical cancer biopsies. The line exhibited a hypodiploid karyotype initially, and an epithelial morphology.
Karyological instability was observed with continued passage. The retinoblastoma protein (pRB) is present but abnormal in size. Expression of p53 is elevated, and there is a point mutation at codon 273 resulting in a Arg -> Cys substitution.
The cells are negative for human papillomavirus DNA and RNA.
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