Nonomuraea solani (ATCC® 53828)

Strain Designations: MA6474  /  Type Strain: no  /  Biosafety Level: 1

Deposited As Unidentified actinomycete
Strain Designations MA6474
Application
Produces immunosuppressant L-685,487 L-685,487
Isolation
Soil
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format freeze-dried
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Disclosure This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC.
Preceptrol® no
Type Strain no
Comments
Bioconversion of Simvastatin
Medium ATCC® Medium 1187: Mannan Salts Medium
ATCC® Medium 196: Yeast malt extract agar
Growth Conditions
Temperature: 26°C
Atmosphere: Aerobic
Name of Depositor Merck & Co., Inc.
U.S. Patent Number
Disclosure This material is cited in a US or other Patent and may not be used to infringe the claims. Depending on the wishes of the Depositor, ATCC may be required to inform the Patent Depositor of the party to which the material was furnished. This material may not have been produced or characterized by ATCC.
Isolation
Soil
References

Arison BH, et al. Microbial transformation product of L-683,990. US Patent 4,975,372 dated Dec 4 1990

Marcin C, et al. Bioconversion of the sodium salt of simvastatin (MK-733) to 6-desmethyl- 6-alpha-hydroxymethyl simvastatin. J. Ind. Microbiol. 8: 157-164, 1991. PubMed: 1367898