Dengue virus type 3 (ATCC® VR-1684)

Classification: Flaviviridae, Flavivirus  /  Product Format: frozen

Classification Flaviviridae, Flavivirus
Agent Dengue virus type 3
Strain Monoclonal anti-Dengue virus type 3 E protein, clone E1 (produced in vitro)
Emerging infectious disease research
Biosafety Level 1
Product Format frozen
Storage Conditions  -20°C or colder Repeated freeze-thaw cycles should be avoided
Antibody Class: IgG2aκ
The B cell hybridoma was generated by the fusion of P3X63.Ag. BALB/c mouse myeloma cells with immunized mouse splenocytes. The clone E1 antibody is reported to bind to domain III in the envelope glycoprotein.
Name of Depositor MS Diamond, Washington University in St. Louis, School of Medicine
Mouse monoclonal antibody prepared against the envelope glycoprotein of dengue virus type 3 was purified from clone E1 hybridoma supernatant by protein G affinity chromatography.

Balsitis SJ, et al. Lethal antibody enhancement of dengue disease in mice is prevented by Fc modification. PLoS Pathog. 6: e1000790, 2012. PubMed: 20168989

Rajamanonmari R, et al. On a mouse monoclonal antibody that neutralizes all four dengue virus serotypes. J. Gen. Virol. 90: 799-809, 2009. PubMed: 19264660