Source culture: heart of mice inoculated by peripheral route with EMC of swine
VR-1479 (M-variant) is a cell culture passaged lineage of the M variant (VR-1314) reported to induce diabetes in selected strains of mice such as Balb/cBy and DBA/2 mice. The virus loses diabetagenic properties upon multiple passage in cell culture.
This strain is adapted to live in tissue culture
Effect on Host
Yes, in vivo effects: Subtle disease: Induction of myocarditis and changes in islets of the pancreas
Yes, in vivo effects: diabetes mellitus (type I) in susceptible mouse strains