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Abstract:

Optimized cell lines are essential for modeling neurodegenerative diseases such as Parkinson’s disease, screening novel therapeutics for preclinical studies, and testing the neurotoxicity of environmental compounds. Neural progenitor cells (NPCs) derived from induced pluripotent stem cells (iPSCs) are excellent in vitro models as they can be induced to differentiate down all three neural lineages. ATCC has recently added a line of NPCs developed from a donor with Parkinson’s disease to its collection of neurological research tools. This webinar will describe how ATCC NPCs can be differentiated into three neural fates and used in toxicological studies, focusing on the performance of the Parkinson’s disease-derived NPCs.

Key Points:

  • ATCC has a wide range of whole-cell models of Parkinson’s disease
  • NPCs cultured in ATCC Dopaminergic Neuron Differentiation Media express tyrosine hydroxylase and TuJ1
  • Parkinson’s disease patient-derived NPCs can be induced to differentiate into all three major neural lineages
  • Parkinson’s disease patient-derived NPCs can be used to screen compounds for toxicity

SOT 2018

Society of Toxicology

3/12/2018 — 3/15/2018

San Antonio, Texas

Booth: 1422

Approximately 6,500 toxicologists from more than 50 countries are expected to share their research and expertise during the 160+ Scientific Sessions, featuring nearly 2,500 abstracts.


Exhibitor-hosted Session

Advanced In Vitro Solute Carrier Transporter Models for Renal Toxicity Studies and Screening
Presenter: Kevin Grady, BS, ATCC; Chaozhong Zou, PhD, ATCC
Location: 217D
March 14, 2018
10:30 AM – 11:30 AM


Posters

Charles Zou

A New Human Renal Solute Carrier Uptake Model for Drug Toxicity Studies
Presenter: Chaozhong Zou, PhD, ATCC
Abstract Number/Poster Board Number: #1557/P783
Location: CC Exhibit Hall

March 12, 2018
1:30 PM – 3:00 PM

Sheela Jacob, PhD

Comprehensive Gene Expression Analysis and Neurotoxicity Testing of Human iPSCs-Derived Neural Progenitor Cells and Neurons
Presenter: Sheela Jacob, PhD, ATCC
Abstract Number/Poster Board Number: #1425/P530
Location: CC Exhibit Hall

March 12, 2018
3:00 PM – 4:30 PM