Cells are immortalized MEFs, which were generated from BAX knockout mice.
Cells are immortalized MEFs (genotype: bax-/-), which were generated from BAX knockout mice.
BAX is a pro-apoptotic BCL-2 family member. Cells are sensitive to tBID-induced cytochrome c release and apoptosis.
Cells are sensitive to multiple apoptotic stimuli that act through disruption of mitochondrial function: staurosporine, ultraviolet radiation, growth factor deprivation, etoposide, and the endoplasmic reticulum stress stimuli thapsigargin and tunicamycin.
Cells are sensitive to Bim and Bad expression induced apoptosis.
This cell line is useful to study molecular mechanism of cell apoptosis, BCL-2 family pathway, BAX function, as well as cells that are resistant to multiple apoptotic stimuli.