Highly purified genomic DNA preparations are critical controls in the development and validation of molecular assays.
ATCC has isolated and purified genomic DNA from a number of the highly characterized, authenticated cell lines in our collection. Specification and characteristics of each lot of genomic DNA includes:
*Quantitative DNA only
ddPCR™ quantitated for high-precision analysis*
Well-characterized genetic alterations
Absolute mutation/amplification copy number*
STR profiling to ensure identity
Mutations such as BRAF, KRAS, and EGFR
Amplifications such as HER2, EFGR, and MYC
The new Quantitative Genomic DNA are especially compatible with several lab-developed and commercially available assays as BSL-1, ready-to-use controls for your assays.
Quantitative Genomic DNA
ATCC qDNA are extracted from patient samples or cell lines that contain biomarkers that have been quantified by validated methods for each product lot. Gene mutation allelic frequency as well as relative and absolute gene copy number are available for each qDNA.
Certified Reference Materials
Human CRM DNA
Genuine Nucleic CRMs are quantified biological reference materials produced under an ISO Guide 34:2009 accredited process to confirm identity, well-defined characteristics, and an established chain of custody. These tools are ideal for use in inclusivity/exclusivity testing, establishing limits of detection, and validating or comparing test methods.