Planned maintenance

We must perform activities that will impact the ability to place orders on our website. Starting Friday, May 21, at 5:00 p.m. Eastern to Sunday, May 23, at 5:00 p.m. Eastern, you will not be able to order products on our website. You will still be able to browse and access your account. We apologize for any inconvenience this work may cause.


FAQ Home

Find Answers

EML4-ALK fusion variant

Which EML4-ALK fusion variant does ATCC® CCL-185IG ™ contain?

The EML4-ALK gene fusion that is caused by a chromosomal inversion can produce constitutively active ALK tyrosine kinase protein, which leads to enhanced cell survival and proliferation. There are multiple EML4-ALK fusion variants, and the most prevalent is variant 1 (E13; A20) where the EML4 intron 13 is fused with ALK intron 20.  The EML4-ALK Fusion-A549 Isogenic cells (ATCC® CCL-185IG ™) was created at ATCC using CRISPR/Cas9 gene editing technology and contains the EML4-ALK fusion variant 1 (E13; A20).
Date Created01/18/2016 10:19 AM
Date Updated01/18/2016 10:20 AM

Most Popular Answers

  1. Huh7 cell line
  2. ATCC HUVEC lines
  3. Passage number vs. population doubling level (PDL)
  4. Converting TCID[50] to plaque forming units (PFU)
  5. U-373 MG (ATCC® HTB-17)