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Significance of IDH1 mutation in BT142 cells
What is the significance of the IDH1 mutation in the BT142 cells?

Mutations in IDH1 are found in approximately 80% of grade II-III gliomas and secondary glioblastomas in humans. A single amino acid residue of IDH1, arginine 132, is most commonly mutated to histidine. This IDH1 R132H mutation results in a gain-of-function to produce oncometabolilte 2-hydroxyglutarate. 
Date Created03/29/2013 12:04 PM
Date Updated03/27/2014 08:41 PM

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