Penicillium brevi-compactum Dierckx, anamorph (ATCC® 9056)

Strain Designations: NRRL 864 [42, 4733.21, ATCC 10418, CBS 257.29, DSM 3825, Dierckx, IMI 40225, MUCL 30241, NRRL 2011, QM 7496]  /  Product Format: freeze-dried

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Strain Designations NRRL 864 [42, 4733.21, ATCC 10418, CBS 257.29, DSM 3825, Dierckx, IMI 40225, MUCL 30241, NRRL 2011, QM 7496]
Application
produces asperphenamate
produces brevianamide A
produces brevianamide B
produces ergosterol
produces hydroxygrindelanes
produces mycophenolic acid
produces insecticide hydroxygrindelanes
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format freeze-dried
Type Strain yes (type strain)
Preceptrol® no
Comments
Transformations of antitumor agents
life cycle
Morphology

Colonies on malt agar growing moderately rapidly, granular, olivaceous-green, reverse yellowish to reddish-brown. Conidiophore stipes smooth-walled; penicillia generally terverticillate. Phialides flask-shaped. Conidia smooth-walled or slightly verruculose, ellipsoidal, 2.5-3.5 µm.

Medium ATCC® Medium 312: Czapek's agar
Growth Conditions
Temperature: 24.0°C
Sequenced Data
      18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence.

CTGCGGAAGGATCATTACCGAGTGAGGGCCCTCTGGGTCCAACCTCCCACCCGTGTTTATTTTACCTTGTTGCTTCGGCGAGCCTGCCTTTTGGCTGCCGGGGGACGTCTGTCCCCGGGTCCGCGCTCGCCGAAGACACCTTAGAACTCTGTCTGAAGATTGTAGTCTGAGATTAAATATAAATTATTTAAAACTTTCAACAACGGATCTCTTGGTTCCGGCATCGATGAAGAACGCAGCGAAATGCGATACGTAATGTGAATTGCAGAATTCAGTGAATCATCGAGTCTTTGAACGCACATTGCGCCCTCTGGTATTCCGGAGGGCATGCCTGTCCGAGCGTCATTGCTGCCCTCAAGCACGGCTTGTGTGTTGGGCTCCGTCCTCCTTCCGGGGGACGGGCCCGAAAGGCAGCGGCGGCACCGCGTCCGGTCCTCAAGCGTATGGGGCTTTGTCACCCGCTTTGTAGGACTGGCCGGCGCCTGCCGATCAACCAAACTTTTTTCCAGGTTGACCTCGGATCAGGTAGGGATACCCGCTGAACTTAAGCATATCAATAAGGCGGAGGAA

Morphology

Colonies on malt agar growing moderately rapidly, granular, olivaceous-green, reverse yellowish to reddish-brown. Conidiophore stipes smooth-walled; penicillia generally terverticillate. Phialides flask-shaped. Conidia smooth-walled or slightly verruculose, ellipsoidal, 2.5-3.5 µm.

Name of Depositor NRRL
Chain of Custody
ATCC <<--NRRL<<--C. Thom 4733.21 <<--- P. Biourge 42, strain Dierckx
Cross References

Nucleotide (GenBank) : JQ070074 ITS including 5.8S rRNA gene

References

Bird BA, Campbell IM. Disposition of mycophenolic acid, brevianamide A, asperphenamate, and ergosterol in solid cultures of Penicillium brevicompactum. Appl. Environ. Microbiol. 43: 345-348, 1982.

Bartman CD. Mycophenolic acid production by Penicillium brevicompactum on solid media. Appl. Environ. Microbiol. 41: 729-736, 1981.

. The genus Penicillium. London: Academic Press; 1979.

Doerfler DL, et al. Spore germination, colony development, and secondary metabolism in Penicillium brevicompactum: a radiogas chromatographic and morphological study. Can. J. Microbiol. 24: 1490-1501, 1978. PubMed: 747811

Chien MM, Rosazza JP. Microbial transformations of natural antitumor agents. 9. O-Demethylation of 9-methoxyellipticine. J. Nat. Prod. 42: 643-647, 1979. PubMed: 575547

Bird BA, Campbell IM. Occurrence and biosynthesis of asperphenamate in solid cultures of Penicillium brevicompactum. Phytochemistry 21: 2405-2406, 1982.

Hoffmann JJ, et al. Hydroxygrindelane derivatives by microbial transformation. Phytochemistry 27: 2125-2127, 1988.

Bird BA, et al. Brevianamides A and B are formed only after conidiation has begun in solid cultures of Penicillium brevicom pactum. Appl. Environ. Microbiol. 42: 521-525, 1981.

Clutterbuck PW, Raistrick H. Studies in the biochemistry of microorganisms. The molecular constitution of the metabolic products of Penicillium brevi-compactum Dierckx and related species. II. Mycophenolic acid. Biochem. J. 27: 654-667, 1933.

type strain

type strain

Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation