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Tolypocladium inflatum Gams, anamorph (ATCC^® 34921^™)

Alternate State: Cordyceps subsessilis Petch, teleomorph / Strain Designations: NRRL 8044 [FERM-P 2796] / Product Format: freeze-dried

Tolypocladium inflatum Gams, anamorph ATCC^® 34921^™

freeze-dried

For-Profit: $354.00 Non-Profit: $295.00

Qty:

Permits	These permits may be required for shipping this product: Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Deposited As	Trichoderma polysporum (Link : Persoon) Rifai, anamorph
Strain Designations	NRRL 8044 [FERM-P 2796]
Alternate State	Cordyceps subsessilis Petch, teleomorph
Application	produces chitinase produces cyclosporin A S-7481/F-1 produces cyclosporin B S-7481/F-2 produces cyclosporin C produces cyclosporin D produces cyclosporin E produces cyclosporin G produces cyclosporin synthetase produces dihydrocyclosporin C produces dihydrocyclosporin G produces isocyclosporin G produces lipase transformation host
Biosafety Level	1
Product Format	freeze-dried
Type Strain	no

Genome Sequenced Strain	Yes
Comments	Genome sequencing strain (Oregon State University, USA)

Medium	ATCC^® Medium 336: Potato dextrose agar (PDA)
Growth Conditions	Temperature: 24°C

Sequenced Data	No DNA sequencing was performed in house on this product.

Name of Depositor	NRRL
Isolation	soil
Cross References	Nucleotide (GenBank) : Z69598 CPA-element Nucleotide (GenBank) : AJ295083 5.8S rRNA and ITS2 Nucleotide (GenBank) : Z28383 cyclosporin synthetase gene Nucleotide (GenBank) : A36768 Sequence 1 from Patent EP0578616. Nucleotide (GenBank) : A36772 Sequence 5 from Patent EP0578616. Nucleotide (GenBank) : A40404 Sequence 31 from Patent WO9425606. Nucleotide (GenBank) : A40406 Sequence 33 from Patent WO9425606. Nucleotide (GenBank) : A40408 Sequence 35 from Patent WO9425606. Nucleotide (GenBank) : A40409 Sequence 36 from Patent WO9425606. Nucleotide (GenBank) : A40410 Sequence 37 from Patent WO9425606. Nucleotide (GenBank) : S80937 lamda clone 6-14, repetitive element Nucleotide (GenBank) : AJ251864 partial tnir1 gene for pathway-specific nitrogen regulator, exons 1-2
References	Offenzeller M, et al. Biosynthesis of the unusual amino acid (4R)-4-[(E)-2-butenyl]-4-methyl-L-threonine of cyclosporin A. J. Biol. Chem. 268: 26127-26134, 1993. PubMed: 8253730 Ruegger A, Kuhn M. Dihydrocyclosporin C. US Patent 4,108,985 dated Aug 22 1978 Harri E, Ruegger A. Organic compounds. US Patent 4,117,118 dated Sep 26 1978 Traber RP, et al. Cyclosporin derivatives, their production and pharmaceutical compositions containing them. US Patent 4,288,431 dated Sep 8 1981 Weber G, et al. The peptide synthetase catalyzing cyclosporine production in Tolypocladium niveum is encoded by a giant 45.8-kilobase open reading frame. Curr. Genet. 26: 120-125, 1994. PubMed: 8001164 Weber G, Leitner E. Disruption of the cyclosporin synthetase gene of Tolypocladium niveum. Curr. Genet. 26: 461-467, 1994. PubMed: 7874740 von Arx JA. Tolypocladium, a synomym of Beauveria. Mycotaxon 25: 153-158, 1986. Kempken F, et al. A unique repeated DNA sequence in the cyclosporin-producing strain of Tolypocladium inflatum (ATCC 34921). Exp. Mycol. 19: 305-313, 1995. PubMed: 8574905 Agathos SN, Lee J. Mathematical modeling of the production of cyclosporin A by Tolypocladium inflatum: effect of L-valine. Biotechnol. Prog. 9: 54-63, 1993. PubMed: 7763411 Kempken F, Kuck U. Evidence for circular transposition derivatives from the fungal hAT-transposon Restless. Curr. Genet. 34: 200-203, 1998. PubMed: 9745022 Lee TH, et al. Development of a cell-loaded biosupport separator for continuous immobilized-cell perfusion culture. Biotechnol. Prog. 15: 267-272, 1999. PubMed: 10194403 Ruegger A, et al. Cyclosporin A, a Peptide Metabolite from Trichoderma polysporum (Link ex Pers.) Rifai, with a remarkable immunosuppressive activity. Helv. Chim. Acta 59: 1075-1092, 1976. PubMed: 950308 Traber R, et al. New cyclopeptides from Trichoderma polysporum (Link ex Pers.) Rifai: cyclosporins B, D and E. Helv. Chim. Acta 60: 1568-1578, 1977. PubMed: 561044 Hoppert M, et al. Structure and localization of cyclosporin synthetase, the key enzyme of cyclosporin biosynthesis in Tolypocladiium inflatum. Arch. Microbiol. 176: 285-293, 2001. PubMed: 11685373 Lee J, Agathos SN. Effect of amino acids on the production of cyclosporin A by Tolypocladium inflatum. Biotechnol. Lett. 11: 77-82, 1989. Aarnio TH, Agathos SN. Production of extracellular enzymes and cyclosporin by Tolypocladium inflatum and morphologically related fungi. Biotechnol. Lett. 11: 759-764, 1989.

Permits	These permits may be required for shipping this product: Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation	Product Sheet Certificate of Analysis MSDS

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Tolypocladium inflatum Gams, anamorph (ATCC^® 34921D-2^™)

dried

DNA INFORMATION:

Total DNA: Approximately 2 µg in 1X TE buffer

OD₂₆₀/OD₂₈₀: 1.7 to 2.1

For-Profit: $290.00 Non-Profit: $290.00