ATCC Virus Reference Materials
Adeno-associated virus (AAV) -based recombinant vectors are important vehicles for clinical gene therapy and other applications. The global availability of AAV reference standard materials (RSMs) permits the standardization of quantification techniques between research and manufacturing organizations. The AAV RSMs are intended for use as internationally accepted standards for the purpose of calibrating internal product-specific reference materials.
We are pleased to announce Adeno-Associated Virus Serotype 2 Reference Standard Material ATCC VR-1616 is available from ATCC and Adeno-Associated Serotype 8 Reference Standard Material ATCC VR-1816 is now available. Both were deposited by the Adeno-associated Virus Reference Standard Working Groups (AAV2RSWG and AAV8RSWG). The pTR-UF-11 vector plasmid ATCC MBA-331 used to produce the reference material, the HeLa RC32 cell line (ATCC CRL-2972), and the human adenovirus type 5 reference material (ATCC VR-1516) used to conduct the infectious titer assay are also available.
Adenovirus Type 5 Reference Material
Recombinant Adeno-Associated Virus 2 Reference Standard Material (AAV2 RSM)
Each vial contains 0.5 mL of AAV2 RSM at 3.28 X 1010 vg/mL, or 4.37 X 109 IU/mL.
AAV2 additional information
Adeno-Associated Virus 8 Reference Standard Material (AAV8 RSM)
This reference material is currently undergoing characterization by the Adeno-associated Virus Reference Standard Working Group (AAV8RSWSG) and is not currently available to the public; when the information becomes available it will be posted with the additional information below.
Each vial contains 0.125 mL of AAV8 RSM.
AAV8 additional information
** Please note that the HEK-293 production cells are not available for sale, and you should plan to use your own cell bank to develop and test your internal reference material.