Candida tropicalis (Castellani) Berkhout (ATCC® 750)

Strain Designations: [1909, ATCC 4563, ATCC 7349, CBS 94, CCRC 20520, DSY 59, IFO 1070, IFO 1400, JCM 1541, NRRL Y-12699, NRRL Y-12968, NRRL Y-607]  /  Product Format: freeze-dried

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Deposited As Monilia tropicalis (Castellani) Castellani et Chalmers
Strain Designations [1909, ATCC 4563, ATCC 7349, CBS 94, CCRC 20520, DSY 59, IFO 1070, IFO 1400, JCM 1541, NRRL Y-12699, NRRL Y-12968, NRRL Y-607]
Assay of chloro-8-quinolinol
Bacterial resistance testing
Degrades xylose D-xylose
Fungus resistance testing adhesives
Produces aspartic proteinases aspartyl proteinases
Produces ethyl alcohol ethanol
Produces xylitol
Susceptibility disc testing
Susceptibility testing
Transformation host
Produces xylitol from D-xylose
Control strain for typing systems
Produces ethanol from D-xylose
Control strain to test oxygen availability in bioreactor in space laboratory
Reference strain for Clinical and Laboratory Standards Institute(CLSI)-developed Antifungal Susceptibility Testing.
Biosafety Level 1
Product Format freeze-dried
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Type Strain yes (type strain)
Genotype ade2/ade2 acp/acp delta::lambda/delta::lambda
Preceptrol® yes
Genome Sequenced Strain


Utilizes phenol, catechol and 3- and 4-methylcatechols as sole carbon source
Esterase activity
MIC of 2-hydroxychalcone, 75 mcg/ml
Adherence to lysophospholipids
Genome sequencing strain (Genolevures Consortium, France; Wellcome Trust Sanger Institute, UK).
For additional infromation, see CLSI M27-A2 (Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts; Approved Standards-Second Edition).
Mitochondrial genome sequenced strain
Sequenced Data
18S ribosomal RNA gene, partial sequence; internal transcribed spacer 1, 5.8S ribosomal RNA gene, and internal transcribed spacer 2, complete sequence; and 28S ribosomal RNA gene, partial sequence


D1D2 region of the 28S ribosomal RNA gene


Name of Depositor A Castellani
Patient with bronchomycosis
Cross References

Nucleotide (GenBank) : AX110837 Sequence 1570 from Patent WO0123604.

Nucleotide (GenBank) : U45749 26S ribosomal RNA gene, partial sequence

Nucleotide (GenBank) : M60308 C. tropicalis small subunit ribosomal RNA.

Nucleotide (GenBank) : M23673 Candida tropicalis (ATCC 750) cytochrome P450 lanosterol

Nucleotide (GenBank) : AF194419 Candida tropicalis multidrug resistance protein (MDR1) gene,

Nucleotide (GenBank) : AF218992 Candida tropicalis strain ATCC 750T 5.8S ribosomal RNA gene,

Nucleotide (GenBank) : M15945 Yeast (C. tropicalis) P450alk gene encoding the alkane-inducible

Nucleotide (GenBank) : M35199 C. tropicalis NADPH-cytochrome P450 reductase gene, complete cds.

Nucleotide (GenBank) : M24894 Candida tropicalis alkane-inducible cytochrome P450 gene, complete

Nucleotide (GenBank) : U00675 Candida tropicalis D-arabinitol dehydrogenase (ARD) gene, complete


Mahmourides, G et al. Ethanol accumulation in cultures of Pachysolen tannophilus on D-xylose is associated with a transition to a state of low oxygen consumption. Bio-Technology 3: 59-62, 1985.

Walther I, et al. Development of a miniature bioreactor for continuous culture in a space laboratory. J. Biotechnol. 38: 21-32, 1994. PubMed: 7765579

Sato M, et al. Growth inhibitory properties of chalcones to Candida. Lett. Appl. Microbiol. 18: 53-55, 1994.

Rudek W. Esterase activity in Candida species. J. Clin. Microbiol. 8: 756-759, 1978. PubMed: 370150

Castellani A. Observations on "tropical broncho-oidiosis". Br. Med. J. 2: 868-869, 1910.

Lentz DL, et al. The anticandidal properties of chlorinated 8-quinolinols. Mycologia 88: 651-654, 1996.

J. Gen. Appl. Microbiol. 19: 171-187, 1973.

Prakobphol A, et al. Specific adherence of Candida tropicalis to lysophospholipids. Biochemistry 33: 9496-9503, 1994. PubMed: 8068624

Vazquez JA, et al. Comparison of restriction enzyme analysis versus pulsed-field gradient gel electrophoresis as a typing system for Torulopsis glabrata and Candida species other than C. albicans. J. Clin. Microbiol. 31: 2021-2030, 1993. PubMed: 8396585

Brenner DJ, et al. Multisite reproducibility of colorimetric broth microdilution method for antifungal susceptibility testing of yeast isolates. J. Clin. Microbiol. 32: 1625-1628, 1994. PubMed: 7929747

Pfaller MA, et al. Selection of candidate quality control isolates and tentative quality control ranges for in vitro susceptibility testing of yeast isolates by National Committee for Clinical Laboratory Standards proposed standard methods. J. Clin. Microbiol. 32: 1650-1653, 1994. PubMed: 7929752

ASTM International Standard Test Methods for Resistance of Adhesive Preparations in Container to Attack by Bacteria, Yeast, and Fungi. West Conshohocken, PA:ASTM International;ASTM Standard Test Method D 4783-01e1.

Winkelhausen E, Kuzmanova S. Microbial conversion of D-xylose to xylitol. J. Ferment. Bioeng. 86: 1-14, 1998.

de Viragh PA, et al. Cloning and sequencing of two Candida parapsilosis genes encoding acid proteases. J. Gen. Microbiol. 139: 335-342, 1993. PubMed: 8436951

Sanglard D, Fiechter A. DNA transformations of Candida tropicalis with replicating and integrative vectors. Yeast 8: 1065-1075, 1992. PubMed: 1293885

Barchiese F, et al. Experimental induction of fluconazole resistance in Candida tropicalis ATCC 750. Antimicrob. Agents Chemother. 44: 1578-1584, 2000. PubMed: 10817712

Kurtzman CP, Robnett CJ. Identification of clinically important ascomycetous yeasts based on nucleotide divergence in the 5' end of the large-subunit (26S) ribosomal DNA gene. J. Clin. Microbiol. 35: 1216-1223, 1997. PubMed: 9114410

Zaugg C, et al. Secreted aspartic proteinase family of Candida tropicalis. Infect. Immun. 69: 405-412, 2001. PubMed: 11119531

type strain

Method for Antifungal Disk Diffusion Susceptibility Testing of Yeast; Approved Guideline. Wayne, PA. Clinical and Laboratory Standards Institute; CLSI M44-A2.

Medical microbiology--Susceptibility testing of microbial pathogens to antimicrobial agents -- Part 84: Microdilution; Special requirements for testing of fungi against antifungal agents. Berlin, Germany:Deutsches Institut fur Normung;DIN DIN 58940-84: 2002, 2002

Souciet JL, et al. Genomic Exploration of the Hemiascomycetous Yeasts: 1. A set of yeast species for molecular evolution studies. FEBS Lett. 487: 3-12, 2000.

Blandin G, et al. Genomic Exploration of the Hemiascomycetous Yeasts: 16. Candida tropicalis. FEBS Lett. 487: 91-94, 2000.

Valach M, et al. Evolution of linear chromosomes and multipartite genomes in yeast mitochondria. Nucleic Acids Res. 39: 4202-4219, 2011.

type strain

Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation