Influenza A virus (H1N1) (ATCC® VR-1668)

Classification: Orthomyxoviridae, Influenzavirus A  /  Product Format: frozen Each vial of VR-1668 contains approximately 100 µL of purified monoclonal antibody in PBS.

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Classification Orthomyxoviridae, Influenzavirus A
Agent Influenza A virus (H1N1)
Strain Monoclonal Anti-Influenza Virus H1 Hemagglutinin (HA), A/South Carolina/1/1918 (H1N1), Clone 5D3 (produced in vitro)
Applications
Emerging infectious disease research
Respiratory research
Influenza Research
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format frozen Each vial of VR-1668 contains approximately 100 µL of purified monoclonal antibody in PBS.
Storage Conditions  Store at -20°C or colder immediately upon arrival Repeated freeze-thaw cycles should be avoided
Comments
Antibody class: IgG2aκ
The B cell hybridoma was generated by the fusion of Sp2/0 BALB/c mouse myeloma cells with splenocytes from mice immunized by DNA vaccination with a plasmid encoding the HA of influenza virus, A/South Carolina/1/1918 (H1N1) and then boosted with whole inactivated virus.
Name of Depositor A Garcia-Sastre
Source
Mouse monoclonal antibody prepared against the H1 hemagglutinin (HA) of influenza virus A/South Carolina/1/1918 (H1N1) was purified from clone 5D3 hybridoma supernatant by protein G affinity chromatography.
References

Manicassamy B, et al. Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines. PLoS Pathog. 6: e1000745, 2010. PubMed: 20126449

Tumpey TM, et al. Existing antivirals are effective against influenza viruses with genes from the 1918 pandemic virus. Proc. Natl. Acad. Sci. USA. 99: 13849-13854, 2002. PubMed: 12368467

Glaser L, et al. A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. J. Virol. 79: 11533-11536, 2005. PubMed: 16103207

Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation