Monoclonal Anti-Influenza A virus (H1N1) H1 Hemagglutinin (HA), A/South Carolina/1/18 (1918), Clone 39E4 (produced in vitro) (ATCC® VR-1670)

Classification: Orthomyxoviridae, Influenzavirus A  /  Product Format: frozen

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Classification Orthomyxoviridae, Influenzavirus A
Agent Monoclonal Anti-Influenza A virus (H1N1) H1 Hemagglutinin (HA), A/South Carolina/1/18 (1918), Clone 39E4 (produced in vitro)
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Product Format frozen
Storage Conditions -20°C or colder. Repeated freeze-thaw cycles should be avoided.
Comments Antibody Class: IgG2ak
The B cell hybridoma was generated by the fusion of Sp2/0 BALB/c mouse myeloma cells with splenocytes from mice immunized by DNA vaccination with a plasmid encoding the HA of influenza virus, A/South Carolina/1/1918 (H1N1) and then boosted with whole inactivated virus.
Name of Depositor A Garcia-Sastre, Mount Sinai School of Medicine
Source Mouse monoclonal antibody prepared against the H1 HA of influenza virus, A/South Carolina/1/1918 (H1N1) was purified from clone 39E4 hybridoma supernatant by protein G affinity chromatography.
References

Fodor E, et al. Rescue of influenza A virus from recombinant DNA. J. Virol. 73: 9679-9682, 1999. PubMed: 10516084

Glaser L, et al. A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. J. Virol. 79: 11533-11536, 2005. PubMed: 16103207

Manicassamy B, et al. Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines. PLoS Pathog. 6: e1000745, 2010. PubMed: 20126449

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