Monoclonal Anti-Influenza A virus (H1N1) H1 Hemagglutinin (HA), A/South Carolina/1/18 (1918), Clone 6B9 (produced in vitro) (ATCC® VR-1669)

Classification: Orthomyxoviridae, Influenzavirus A  /  Product Format: frozen

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Classification Orthomyxoviridae, Influenzavirus A
Agent Monoclonal Anti-Influenza A virus (H1N1) H1 Hemagglutinin (HA), A/South Carolina/1/18 (1918), Clone 6B9 (produced in vitro)
Biosafety Level 1
Product Format frozen
Storage Conditions -20°C or colder. Repeated freeze-thaw cycles should be avoided.
Comments Antibody Class: IgG2ak
The B cell hybridoma was generated by the fusion of Sp2/0 BALB/c mouse myeloma cells with splenocytes from mice immunized by DNA vaccination with a plasmid encoding the HA of influenza virus, A/South Carolina/1/1918 (H1N1) and then boosted with whole inactivated virus.
Name of Depositor A Garcia-Sastre, Mount Sinai School of Medicine
Source Mouse monoclonal antibody prepared against the H1 HA of influenza virus, A/South Carolina/1/1918 (H1N1) was purified from clone 6B9 hybridoma supernatant by protein G affinity chromatography.
References

Fodor E, et al. Rescue of influenza A virus from recombinant DNA. J. Virol. 73: 9679-9682, 1999. PubMed: 10516084

Glaser L, et al. A single amino acid substitution in 1918 influenza virus hemagglutinin changes receptor binding specificity. J. Virol. 79: 11533-11536, 2005. PubMed: 16103207

Manicassamy B, et al. Protection of mice against lethal challenge with 2009 H1N1 influenza A virus by 1918-like and classical swine H1N1 based vaccines. PLoS Pathog. 6: e1000745, 2010. PubMed: 20126449

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