hLDLR-lambda25 (ATCC® 57244)

Organism: Homo sapiens, human  /  Clone Type: Clone  /  Depositors: DW Russell

Permits and Restrictions

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Designations hLDLR-lambda25
Species Homo sapiens, human
Depositors DW Russell
Vector
Construct size (kb): 46.0
Insert
DNA: genomic
Insert lengths(kb): 14.0
Tissue: liver
Gene product: low density lipoprotein receptor (familial hypercholesterolemia)(low density lipoprotein receptor) [LDLR]
Alleles: A2, E1, E2, A1, A2, B1, B2, D1, D2, K1, K2, Q1, Q2, S2, A1, S1
Insert Size (kb) 14.0
Biosafety Level 1

Biosafety classification is based on U.S. Public Health Service Guidelines, it is the responsibility of the customer to ensure that their facilities comply with biosafety regulations for their own country.

Shipping Information Distributed: freeze-dried bacteria-free lysate
Comments
Restriction digests of the clone give the following sizes (kb): EcoRI--19.8 left arm; 10.9 right arm; 10, 3.6, 2.0 insert.
This probe contains exons 2-6. It encodes the LDL-binding domain which includes 7 Cys-rich 40-amino acid repeats.
References

Sudhof TC, et al. The LDL receptor gene: a mosaic of exons shared with different proteins. Science 228: 815-822, 1985. PubMed: 2988123