hLDLR-lambda25 (ATCC® 57244)

Organism: Homo sapiens, human  /  Clone Type: Clone  /  Depositors: DW Russell

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Designations hLDLR-lambda25
Species Homo sapiens, human
Depositors DW Russell
Vector
Construct size (kb): 46.0
Insert
DNA: genomic
Insert lengths(kb): 14.0
Tissue: liver
Gene product: low density lipoprotein receptor (familial hypercholesterolemia)(low density lipoprotein receptor) [LDLR]
Alleles: A2, E1, E2, A1, A2, B1, B2, D1, D2, K1, K2, Q1, Q2, S2, A1, S1
Insert Size (kb) 14.0
Biosafety Level 1
Shipping Information Distributed: freeze-dried bacteria-free lysate
Comments
Restriction digests of the clone give the following sizes (kb): EcoRI--19.8 left arm; 10.9 right arm; 10, 3.6, 2.0 insert.
This probe contains exons 2-6. It encodes the LDL-binding domain which includes 7 Cys-rich 40-amino acid repeats.
References

Sudhof TC, et al. The LDL receptor gene: a mosaic of exons shared with different proteins. Science 228: 815-822, 1985. PubMed: 2988123

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