Springer TA, et al. Intercellular adhesion molecules, and their binding ligands. US Patent 5,284,931 dated Feb 8 1994
Mice were immunized with the EBV-transformed human lymphoblastoid cell line JY.
The antibody binds to ICAM-1(CD54), and inhibits the interaction of ICAM-1 with leukocytes via lymphocyte function antigen 1(LFA-1, CD11a/CD18).