immunoglobulin; monoclonal antibody; against a human astrocytoma cell line; gp120 glycoprotein
Animals were immunized with the SK-MG-17 human astrocytoma cell line.
The antibody reacts with a glycoprotein (gp120) of relative molecular weight 120000 daltons.
The antigen is expressed on cultured human fibroblasts and sarcomas.
In normal tissues, S5 antigen expression is limited to visceral smooth muscle.
In a survey of tumors, S5 staining was limited to a subset of leiomyosarcomas and the staining was generally weaker than that with normal smooth muscle.