Panels by Tissue Type ATCC has designed tumor cell panels based on the tissue of tumor origin, each annotated with details regarding known mutations - enabling more intelligent choices when selecting cell-based research models. Bladder Cancer Cell Panels Bladder tumor cell lines containing mutations in one or more of the following genes: PIK3CA, RB1, RAS, TSC1, CDKN2A, PTEN, and TP53 Bone Cancer Cell Panels Bone cancer cell lines containing mutations in one or more of the following genes: CDKN2A, BRAF, TP53, RB1, and PTEN. Brain Cancer Cell Panels ATCC has developed two brain cancer cell line panels with varying degrees of genetic complexity, including mutations in TP53 and PTEN. Breast Cancer Cell Panels The ATCC Breast Cancer Cell Panel reflects important genomic abnormalities found in primary breast tumors, which may reveal how they contribute to breast cancer pathologies. Colon Cancer Cell Panels ATCC has developed two colon cancer panels with varying degrees of genetic complexity, and organized by BRAF or KRAS mutations. Gynecologic Cancer Cell Panel A selection of tumor cell panels focused on gynecologic cancers. While the Ovarian, Uterine and Cervical Cancer Cell Panels focus on specific tissue types, the Gynecological Cancer Cell Panel represents a robust blend of tissue sources, including vulva, cervix, ovary and endometrium. Head/Neck Cancer Cell Panels The head and neck cancer cell panel represents cultures with varying degrees of genetic complexity, isolated from salivary gland, tongue, hypopharynx and pharynx. Leukemia Cell Panels The leukemia cancer cell panel represents a diverse collection of Acute Myeloid (AML), Acute Monocytic (AMoL), Chronic Myeloid (CML), and Acute Lymphoblastic (ALL) Leukemia. Lymphoma Cell Panels In an effort to aid biomarker and novel therapeutic discovery, as well as the development of early detection methods that are rapid and accurate, ATCC has assembled lymphoma cell panels to accelerate new discoveries in lymphoma research. Liver Cancer Cell Panels ATCC has developed a liver cancer cell panel from cultures displaying varying degrees of genetic complexity, including mutations in BRAF, CTNNB1, and STK11 Lung Cancer Cell Panels Lung cancer cell lines with varying degrees of genetic complexity, including mutations in EGFR, RAS, PIK3, and TP53. Melanoma Cancer Cell Panels ATCC has developed 2 melanoma cancer cell panels with varying degrees of genetic complexity, representing both primary and metastatic tumors. Molecular Signature Panels ATCC has designed a set of cell panels to help investigators examine the genetic and functional abnormalities of cell signaling pathway components responsible for cancer, autoimmunity, diabetes and many other diseases. Pancreatic Cancer Cell Panels Pancreatic cancer cell lines with varying degrees of genetic complexity, including mutations in FBXW7, RAS, MAP2K4, SMAD4, and TP53. Soft-Tissue Sarcoma Cell Panels A virtual panel of 6 soft-tissue tumor cell lines with varying degrees of genetic complexity. Each culture contains genomic mutations in one or more of the following genes according to the Sanger COSMIC database: CDKN2A, IDH1, NRAS, BRAF, PTEN, and TP53. Stomach Cancer Cell Panels ATCC has organized a panel of stomach cancer cell lines isolated from both primary and metastatic sites, including mutations in TP53, SMAD4, CDH1, and CTNNB1.