FGFR Genetic Alteration Cell Panel (ATCC® TCP-1034)

Organism: Homo sapiens, human  / 

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Organism Homo sapiens, human
Components ATCC HTB-23 MDA-MB-134-VI
ATCC CRL-2066 DMS 114
ATCC CCL-235 SW837
ATCC CCL-246 KG-1
ATCC CCL-247 HCT116
ATCC CRL-5974 SNU-16
ATCC HTB-103 KATO III
ATCC CRL-1739 AGS
Applications This validated panel is composed of 8 select human cancer cell lines carrying various degrees of FGFR1 and FGFR2 amplification, and is useful for FGFR pathway research and for anti-cancer drug discovery.
Biosafety Level 2  [Cells contain Parainfluenza virus type 5]
Comments

Fibroblast Growth Factor Receptors (FGFRs), are transmembrane tyrosine kinase receptors that induce intracellular tyrosine kinase activity when bound to Fibroblast Growth Factor.  FGFR plays crucial roles in development and cell growth. Upregulation of the FGF/FGFR signaling pathway leads to induction of mitogenic and survival signals, as well as promoting epithelial-mesenchymal transition, invasion and tumor angiogenesis. Amplification or activation of FGFR1 and FGFR2 genes has been linked to several cancer types such as lung cancer, breast cancer and gastric cancer. 

The FGFR genetic alteration cell panel (ATCC TCP-1034) is composed of eight selected human tumor cell lines from common cancer types that carry various gene copy number amplification within the FGFR1 or FGFR2 genes. The FGFR1 or FGFR2 status of each cell line has been validated by ATCC. This panel is useful for FGFR pathway research and FGFR inhibitors anti-cancer drug discovery.

Product Format 8 cryopreserved cell lines
Storage Conditions liquid nitrogen vapor phase (less than -130°C) only
Notice: Necessary PermitsPermits

These permits may be required for shipping this product:

  • Customers located in the state of Hawaii will need to contact the Hawaii Department of Agriculture to determine if an Import Permit is required. A copy of the permit or documentation that a permit is not required must be sent to ATCC in advance of shipment.
Basic Documentation
Other Documentation
FAQs
  1. Tumor Cell Panels


    Date Updated: 3/27/2014

  2. Nucleic acids and cell pellets for ATCC Cell Panels


    Date Updated: 3/27/2014

  3. Molecular Signature Panels

    Date Updated: 3/27/2014
  4. Control cell line for tumor cell panels


    Date Updated: 3/27/2014

  5. Validated genetic information for tumor cell panels
    It depends on the types of panels. There are mainly two kinds ...
    Date Updated: 3/27/2014
  6. Tumor cell panels by tissue type vs. molecular signature


    Date Updated: 3/27/2014

  7. Tumor cell panels by tissue type


    Date Updated: 3/27/2014

  8. Gene mutation information for molecular signature panels


    Date Updated: 3/27/2014