Building a Zika virus vaccine

From global health to virus–like particle technology

2/14/2019


Abstract: 

Zika virus is a mosquito-borne flavivirus that is associated with a wide range of congenital abnormalities and neurological disorders. Currently, there are no vaccines or antiviral strategies approved for use in the prevention or treatment of Zika. As part of our pledge to support global health, ATCC has developed several novel Zika virus-like particle (Zika-VLP)–based vaccine candidates that are designed to elicit a specific antibody response and provide interstrain protection. In this webinar, we will discuss the development of these vaccine candidates and will provide data demonstrating their ability to induce a strong immune response and provide a high level of protection against Zika virus in murine animal models.  

Key Points: 

  • We have developed a chimeric Zika-VLP–based vaccine that elicits a protective immune response and prevents antibody-dependent enhancement (ADE) and Guillian Barré Syndrome (GBS) in murine animal models. 
  • Zika-VLPs containing the CD loop sub-structural domain from envelope protein domain III induced a strong antibody response against the Zika virus in mouse models after prime immunization. 
  • The protective immunity of our novel Zika-VLP vaccine candidates is mediated by antibody-dependent cell-mediated cytotoxicity and complement-dependent cytotoxicity.

Presenters

Velasco Cimica

Velasco Cimica, Ph.D.,
Scientist, ATCC

Dr. Cimica is a Scientist at ATCC with over 10 years of experience working in virology. Dr. Cimica is an expert in vaccine development using virus-like particles (VLPs) for respiratory syncytial virus, dengue virus, and Zika virus, and he is currently developing VLP-based vaccine candidates for emerging viruses. He applies structural vaccinology and rational design approaches for the creation of novel and optimized vaccine candidates. In addition, Dr. Cimica has demonstrated experience in adjuvant formulation and optimization specifically for VLP-based vaccines.