Histoplasma capsulatum Darling, anamorph (ATCC® 26032)

Alternate State: Ajellomyces capsulatus (Kwon-Chung) McGinnis et Katz, teleomorph  /  Strain Designations: G-217B  /  Product Format: frozen

Strain Designations G-217B
Alternate State Ajellomyces capsulatus (Kwon-Chung) McGinnis et Katz, teleomorph
Application
Biomedical Research and Development Material
Emerging infectious disease research
Respiratory research
Biosafety Level 3
Product Format frozen
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Type Strain no
Preceptrol® no
Genome Sequenced Strain

Yes

Comments
iron acquisition mechanisms
fungistasis
neutralization of interleukin-12
yeast phase
effect of continuous light and total darkness
effect of pH
differentiation of A and B phenotypes
temperature-tolerant, high virulence; analysis of yps-3 gene
Genome sequencing strain (The Genome Sequencing Center (GSC) at Washington University, USA).
Medium Medium 28: Emmons' modification of Sabouraud's agar
Growth Conditions
Temperature: 25.0°C
Name of Depositor MD Berliner
Chain of Custody
ATCC <<--MD Berliner<<--J.H. Seabury
Isolation
human, Louisiana
Cross References

Nucleotide (GenBank) : AF026268 M antigen gene, complete coding sequence

Nucleotide (GenBank) : AF139985 catalase B (CATB) mRNA, complete coding sequence

Nucleotide (GenBank) : AF189368 catalase isozyme A (CATA) mRNA, complete coding sequence

Nucleotide (GenBank) : AF189369 catalase isozyme P (CATP) mRNA, complete coding sequence

Nucleotide (GenBank) : L16844 Histoplasma capsulatum yeast phase specific (yps-3) gene, complete

Nucleotide (GenBank) : L16845 Histoplasma capsulatum yeast phase specific (yps-3) mRNA, 3' end of

Complete Genome (GenBank) : ABBT00000000 Ajellomyces capsulatus G217B, whole genome shotgun sequencing project

References

Keath EJ, Abidi FE. Molecular cloning and sequence analysis of yps-3, a yeast-phase-specific gene in the dimorphic fungal pathogen Histoplasma capsulatum. Microbiology 140: 759-767, 1994. PubMed: 8012597

Berliner MD, Biundo N Jr.. Effects of continuous light and total darkness on cultures of Histoplasma capsulatum. Sabouraudia 11: 48-51, 1973. PubMed: 4703465

Berliner MD. Histoplasma capsulatum: effects of pH on the yeast and mycelial phases in vitro. Sabouraudia 11: 267-270, 1973. PubMed: 4128915

Berliner MD. Histoplasma capsulatum: vital staining for the differentiation of the albino and brown phenotypes in vitro. Sabouraudia 11: 271-273, 1973. PubMed: 4128916

Weaver CH, et al. Localization of a yeast-phase-specific gene product to the cell wall in Histoplasma capsulatum. Infect. Immun. 64: 3048-3054, 1996. PubMed: 8757832

Timmerman MM, Woods JP. Ferric reduction is a potential iron acquisition mechanism for histoplasma capsulatum. Infect. Immun. 67: 6403-6408, 1999. PubMed: 10569756

Cain JA, Deepe GS Jr.. Interleukin-12 neutralization alters lung inflammation and leukocyte expression of CD80, CD86, and major histocompatibility complex class II in mice infected with Histoplasma capsulatum. Infect. Immun. 68: 2069-2076, 2000. PubMed: 10722603

Sorensen KN, et al. Murine models of blastomycosis, coccidioidomycosis, and histoplasmosis. Mycopathologia 146: 53-65, 1999.

Newman SL, et al. Identification of constituents of human neutrophil azurophil granules that mediate fungistasis against Histoplasma capsulatum. Infect. Immun. 68: 5668-5672, 2000. PubMed: 10992469

Johnson CH, et al. Redundancey, phylogeny and differential expression of Histoplasma capsulatum catalases. Microbiology 148: 1129-1142, 2002. PubMed: 11932457

Magrini V, et al. Fosmid-Based Physical Mapping of the Histoplasma capsulatum Genome. Genome Res. 14: 1603-1609, 2004.