PI3K Genetic Alteration Cell Panel (ATCC® TCP-1028)

Organism: Homo sapiens, human  / 

Organism Homo sapiens, human
Components ATCC CCL-225 HCT-15
ATCC CCL-237 SW948
ATCC CRL-1739 AGS
ATCC CRL-2577 RKO
ATCC HTB-112 HEC-1-A
ATCC HTB-121 BT-483
ATCC HTB-131 MDA-MB-453
ATCC HTB-178 NCI-H596
ATCC HTB-19 BT-20
ATCC HTB-27 MDA-MB-361
Applications This panel is useful for PI3K pathway research and for anti-cancer drug discovery.
Biosafety Level 2 [Cells contain Parainfluenza virus type 5]
Comments

The Phosphoinositide 3‑kinases (PI3Ks) family of enzymes is integral to several signaling pathways that mediate cell proliferation, survival, migration and vesicular trafficking. Member of the PI3K family are frequently mutated or altered in human cancers. For example, gain-of-function mutations in p110α (encoded by the PI3KCA gene) are observed in a variety of common cancers; and, these mutations are exclusively clustered in one of two hotspot regions, (i.e., exon 9 and 20), which correspond to either the helical or kinase domains of the protein (e.g., E545K and H1047R).

The PI3K Genetic Alteration Cell Panel (ATCC TCP-1028) is composed of ten human tumor cell lines from common cancer types that carry hotspot mutations within the PIK3CA gene. The PI3KCA status of each cell line has been sequenced and validated by ATCC. This panel is useful for PI3K pathway research and for anti-cancer drug discovery.

Product Format frozen
Storage Conditions LN vapor (less than -130°C) only
Basic Documentation
Other Documentation
FAQs
  1. Tumor Cell Panels


    Date Updated: 3/27/2014

  2. Nucleic acids and cell pellets for ATCC Cell Panels


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  3. Molecular Signature Panels

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  4. Validated genetic information for tumor cell panels
    It depends on the types of panels. There are mainly two kinds ...
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  5. Tumor cell panels by tissue type vs. molecular signature


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  6. Tumor cell panels by tissue type


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  7. Control cell line for tumor cell panels


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  8. Gene mutation information for molecular signature panels


    Date Updated: 3/27/2014