Streptomyces avermitilis (ex Burg et al.) Kim and Goodfellow (ATCC® 31267)

Strain Designations: NRRL 8165 [JCM 5070, MA-4680, NCIMB 12804]  /  Type Strain: yes  /  Biosafety Level: 1

Deposited As Streptomyces avermitilis
Strain Designations NRRL 8165 [JCM 5070, MA-4680, NCIMB 12804]
Application
Produces avermectin avermectins, avermectin B(1)a C-076, and C-076 and derivatives.
Isolation
Soil, Ito City, Shizuoka Pref., Japan
Type Strain yes
Biosafety Level 1
Product Format freeze-dried
Storage Conditions Frozen: -80°C or colder
Freeze-Dried: 2°C to 8°C
Live Culture: See Propagation Section
Preceptrol® no
Genome Sequenced Strain

Streptomyces avermitilis MA-4680 DNA, complete genome.

Type Strain yes
Comments
Genome sequenced strain
Medium Medium 184: Glucose asparagine agar
Growth Conditions
Temperature: 26°C
Atmosphere: Aerobic
Name of Depositor NRRL
Special Collection NSF - Bacteriology
Chain of Custody
ATCC <-- NRRL <-- Merck & Co., Inc. MA-4680
Isolation
Soil, Ito City, Shizuoka Pref., Japan
References

Burg RW, et al. Avermectins, new family of potent anthelmintic agents: Producing organism and fermentation. Antimicrob. Agents Chemother. 15: 361-367, 1979. PubMed: 464561

Goegelman RT, et al. Novel C-076 compounds. US Patent 4,378,353 dated Mar 26 1983

Hafner EW, et al. Cultures for production of B avermectins. US Patent 5,565,359 dated Oct 15 1996

Ikeda H, et al. Complete genome sequence and comparative analysis of the industrial microorganism Streptomyces avermitilis. Nat. Biotechnol. 21: 526-531, 2003. PubMed: 12692562

Kim SB, Goodfellow M. Streptomyces avermitilis sp. nov., nom. rev., a taxonomic home for the avermectin-producing streptomycetes. Int. J. Syst. Evol. Microbiol. 52: 2011-2014, 2002. PubMed: 12508861

Miller TW, et al. Avermectins, new family of potent anthelmintic agents: Isolation and chromatographic properties. Antimicrob. Agents Chemother. 15: 368-371, 1979. PubMed: 464562

Ormond RE. 22-Hydroxy derivatives of C-076 compounds, pharmaceutical compositions and method of use. US Patent 4,412,991 dated Nov 1 1983

Cross References

Nucleotide (GenBank) : AY029771 Streptomyces avermitilis ribosomal protein S12 (rpsL) gene, complete cds.

Nucleotide (GenBank) : BA000030 Streptomyces avermitilis MA-4680 DNA, complete genome.